The closure is between Louser Road and Meadow Lane, according to PennDOT.
The crash happened shortly after 11 a.m. but the area remained closed off as of 3 p.m. Hazmat was called to the scene around 11:15, according to Lebanon County Emergency Management.
Crews arrived to find one person trapped in a car and a tractor-trailer leaking diesel fuel onto the roadway, according to crews called to the scene.
One person was airlifted from the scene, according to Campbell town Volunteer Fire Company.
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